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There were no serious adverse effects at these doses.
The pharmacokinetic and related pharmacodynamic properties of buprenorphine at these doses have not been characterized.
At these doses, both haloperidol and risperidone produced mild sedative-like effects compared to placebo.
At these doses no toxicity or weight loss was observed for either compound.
We conclude that the combination of carboplatin, vinorelbine, and radiotherapy is feasible at these doses.
At these doses, the cell toxicity experiments show no effect on the cell growth.
We conclude that oral pilocarpine at these doses effectively and safely reduces the symptoms of radiation-induced xerostomia.
In patients with hypertension, dose-dependent BP reduction occurs with aliskiren 75 300 mg once daily; at these doses, the safety and tolerability profile is comparable to placebo.
Buspirone reduced stretch-attend postures at the 10 and 30 mg/kg s.c. doses (Table 1); however, these effects may also reflect the reduced locomotor activity at these doses.
However, mortality at these doses is substantial, from 80 to 100% [17 19].
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Early phase I/II trials conducted in relapsed leukemia estimated an 18% incidence of severe fludarabine neurotoxicity at these doses.
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