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Limited proteolysis confirmed the location of some loops at the surface of the protein 3D model.
The extra seventh helix is located at the surface of the protein, locked by the fourth disulfide bridge, and forms a wall of the internal cavity.
Proteins in solution are expected to constantly undergo reversible, miniature "sub-globally cooperative unfolding/refolding" events (Maity et al. 2005), such as "fraying" at the ends of helices, or even partial unfolding of small regions at the surface of the protein (Chamberlain et al. 1996).
After five cycles of DNA shuffling and selection for t-PA binding, analysis of 27 randomly picked clones revealed that PAI-1 mutants contained an average of 9.1 amino acid substitutions distributed over 114 different positions, which were preferentially located at the surface of the protein.
Residue 248 is located at the surface of the protein and part of an antibody recognition site [26].
In addition, a low-occupancy HI-6 binding site at the surface of the protein is implied by several residual positive electron densities found close to the His287-Ser293 loop region.
Similar(23)
This reflects the high gradient of the electrostatic potential at the ∼0.3 nm range from the surface of the protein.
Gleevec cuts off this signaling by slipping into a pocket on the surface of the signaling protein.
PSA (promastigote surface antigen) is one of the major classes of membrane proteins present at the surface of the parasitic protozoan Leishmania.
Look at the surface of the leaves.
This can result in increased polarity and charge at the surface of a halophilic proteins [ 30].
More suggestions(16)
at the surface of the film
at the surface of the cell
at the structure of the protein
at the surface of the head
at the surface of the biosensor
at the expense of the protein
at the surface of the ocean
at the surface of the device
at the start of the protein
at the surface of the soup
at the surface of the absorber
at the evaluation of the protein
at the level of the protein
at the surface of the titanium
at the surface of the moon
at the surface of the sample
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