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Look at the substitutions and then ask yourself what you are reading.
We propose that the enhanced interaction between Fc/YTE and human FcRn is likely mediated by local effects at the substitutions sites.
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This amounts to considering β k as the "substitution effect", at the population level, of the haplotype.
Van Persie himself was even caught by the television cameras mouthing his shock at the substitution.
To decipher the specific mechanisms of such distance dependence we analyzed the amino acid content of coevolved site pairs at the substitution quads (see Methods) extracted from each pair of protein sequences within the multiple sequence alignment.
These methods also primarily use features based on observed residue preferences at the substitution position.
Compound VPC-16040, with a fourfold benzene substitution, lost its peptide displacement activity fivefold because of the decrease of hydrophobicity at the substitution position.
We are currently investigating the scope of this modification, especially its tolerance to β-branched amino acids at the substitution site and its application to longer targets.
Positive contribution for electrostatic descriptor shows a requirement of electropositive group at the substitution site and an electronegative group in case of negativeshi contribution.
AANATA is less tolerant of substitution at the α-substitution of the ethylamine moiety or changing the length of the methylene spacer between the amino group and the ring.
According to the table of genetic code, most substitutions at the first codon position and all the substitutions at the second codon position are nonsynonymous.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com