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Although all compounds exhibited stronger channel block activities in comparison to memantine in Xenopus oocytes voltage clamped at −70 mV, only compound 2 (0.4 mg/kg intravenous injection) decreased the size of brain infarction in a photochemically induced thrombosis model mice at the same extent of memantine (10 mg/kg intravenous injection).
As shown, transfecting both the cell lines with the TrkB-specific siRNA for 72 h inhibits RA-induced Ret activation, but not expression, at the same extent of treating the cells with Ret specific siRNA (compare lanes 4 to 5, left and right panels).
Interestingly, when the average diameters were plotted against the corresponding conversion levels instead of time, it was obvious that higher impeller speeds caused smaller particle size even at the same extent of hydrolysis.
The previously demonstrated tight link between longevity and fecundity is weakening since methionine addition, one of the essential amino acids, has been demonstrated to be sufficient to increase fecundity at the same extent of full feeding but had no influence on lifespan, raising the possibility that the trade-off between fecundity and longevity is not a mandatory scenario [ 47].
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Therefore, objective evidence that LRH can achieve at least the same extent of resection as in RH should be provided before using them interchangeably.
This fixed s.c. dose should therefore ensure at least the same extent of receptor saturation as i.v. dosing and so provide therapeutic efficacy from the first cycle.
Examination of H3K4me3 and H3K27me3 marks showed that 3-day drug treatment, followed by 3-day washout triggered at least the same extent of change (i.e., increase in H3K27me3), as continuous drug treatment.
Along the same lines of protection in best interests, only therapeutic research that has a clear prospect of benefiting the individual participant to at least the same extent of the current alternative treatments is permitted to carry more than a minimal risk of harm or distress to subjects [ 19- 21] (see Appendix 4).
They're not involved in issuing loans that they shouldn't have for real estate or mortgage financing brokers and things of that sort or at least not to the same extent of some of the biggies.
At 10 °C, all constructs demonstrate virtually the same extent of self-association, −3.59 ± 0.03 kcal/mol.
She underwent the same operation as the first patient, with the same extent of resection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com