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However, if a spontaneous origin of atypical scrapie is the rule, then the disease will stay present at the observed level.
In the first experiment (control run) the concentration of greenhouse gases is set constant at the observed level 1971 1980 (recent climate conditions).
This leaves the prevalence of double carriage intact at the observed level of approximately 11%, while explaining competition with both reduced acquisition (θ ≈ 0.3) and enhanced clearance (φ ≈ 3).
In order to determine whether the stochastic process of accumulation of indel substitutions has reached saturation at the observed level of evolutionary divergence, we examined the number of insertions and deletions per unit of evolutionary distance (supplementary fig. 3, Supplementary Material online).
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Therefore, although low-level exposure to the most common TBECH, TBECH-β, may not induce high AR activation, these compounds may nonetheless induce transgenerational effects at the observed levels.
In the absence of either vertical (Fig. 2A) or systemic transmission (Fig. 2C), the pathogen persists in the tick population at or above the observed level of >0 5%, while in the absence of cofeeding transmission the pathogen cannot be maintained (Fig. 2B).
The particularly high contents observed in samples 208 and 204 could be related to the high Pb content at site C. Indeed, the observed level of Pb contamination is considered harmful for human health.
Moreover, overexpression of LMP-1 alone by in vitro transduction of primary keratinocytes at a level drastically greater than the observed level in tissue samples resulted in no altered filaggrin expression levels (Figure S7).
At a percentage of 69%, the observed level of adherence to the T2T recommendations was probably optimal, as striving for 100% adherence is not realistic because treatment of patients is subject to side effects and comorbidities.
Compounds that performed at ≥30% of the observed levels for positive control (based on artemisinin's enhancement) were selected for secondary screening.
The unit of analysis was the patient and as these results were reported at the raw, observed level, they cannot be assumed to be nationally representative.
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