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However weak, an LD of this magnitude could potentially affect allele distributions at the linked locus and induce a secondary association, but in the case of the HLA-A*02 allele this possibility is rejected by the results of the logistic regression analysis (P = 8.4×10−10).
Population differentiation at the QTL will therefore not be visible at the linked marker.
We calculated the variance of the allele frequency at the linked neutral locus L at the corresponding t nearlyfixed.
Paternal allele-specific DNA methylation is initially acquired at similar stages of post-implantation development at the linked Dlk1 and Gtl2 differentially methylated regions (DMRs).
Consistent with previous findings (Poltoratsky et al., 2010), induction of I-SceI expression resulted in an increased frequency of deaminase-dependent selectable mutation at the linked CAN1 locus.
On the other hand, LD markers provide information to model both the mean and covariances at the linked QTL [ 7- 11].
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