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To study the role of residues at the interacting and non-interacting surface of C3d on the adjuvanticity, single as well as a double residue substitutions were engineered in the murine C3d (R162A, D163A, N170R and D163A N170R) gene.
We especially focused on charge compensatory quads where the fitness of opposite charge interactions is generally preserved by compensating the impact of substitutions at the interacting residues during the course of evolution.
In vitro studies showed that the avidity of C3d for CR2 is affected by residues located at the interacting surface (e.g. 170N) as well as by residues located in other areas.
The structural dispersion of the tail regions might reflect the process of speciation by individual structural adaptations at the interacting surface between the beta- and alpha-subunit of each species.
The gene for this protein is located at the interacting loci on chromosome 4.
The microvilli were in part thicker at the interacting site and some budding was observed.
Similar(39)
Six of the students have finished their courses at the Interact Centre and the remaining 12 will be given alternative provision at West Middlesex College.
He played long, tensile eighth-note lines, rocking calmly at the keyboard, interacting with the changing patterns from the rhythm section.
Finally, we determined that both isoforms of the AT-Rich Interacting Domain 4B (ARID4B) protein could induce G1 arrest when overexpressed.
A similar relationship has been reported for the phosphorylation at Ser10 interacting with the adjacent K9 methylation sites in H3 31.
"He really enjoys being at the wash and interacting with the customers".
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