The phrase "at the imputed" is not correct and does not convey a clear meaning in written English.
It may be intended to refer to something related to "imputed" values or concepts, but without additional context, it is unclear when it could be used.
Example: "The results were analyzed at the imputed values, leading to a more accurate conclusion."
Alternatives: "at the estimated" or "at the inferred".
However, we obtained p = 0.006 for association at the imputed SNP rs296410 that showed the highest R2 with rs702543 in the Hap Map CEU samples (R2 = 0.51); in our study, the major allele (T, frequency 0.52) at rs296410 shows a positive linear association with EPQ-N score.
When testing association at the imputed potential causal SNP, all methods had correct type-I error rates that were close to the target level 5% under all conditions.
All studies contributing directly typed data for this variant (46 066 individuals with directly typed data) show no evidence for association, indicating that the signal observed at the imputed variant may be an artefact.
At rs907715, the imputed WTCCC genotype data also revealed a weak association (Table 3; OR = 0.92 (0.84 to 1.00), P = 0.055).
The numbers of reads carrying each possible allele (with respect to the positive strand) at all of the imputed heterozygous positions (after filtering using the Bisulfite sequencing data as described above) were determined for each histone modification.
In total, 19 and 10 covariates were retained at least once across the imputed data sets for the best and tolerance model respectively.
In the WM setting, considering the case where variables were retained in at least 50% of the imputed data sets, the correct model was selected about 97.6% and 75.7% of the time for the best and tolerance models respectively.
Therefore, particularly in light of the clear replication at the best genotyped tag SNP, the lack of replication in the imputed data at P < 0.05 may be due in part to the loss of statistical power which results from the increased noise (imputation uncertainty) in the inferred genotypes (41).
The imputed genotypes at the "masked" SNPs were then compared with the experimental (typed) genotypes from Omni1 GWAS data to assess the accuracy of imputation.
Within each imputed dataset, we dichotomised the imputed pain at 24 months in accordance with the definition of a response (final pain score <70% of baseline).
The default parameters of the program were used throughout and the most likely genotype was taken to be the imputed genotype at masked loci.
