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Alternatives: "in supplementary materials" or "in supplementary resources".
Since NRG4 levels in serum remained unchanged in Bmp8b TG and Bmp8b /– mice compared to their respective WTs, we posited a potential local action within AT (Supplementary Figure 4f, g).
The 24-mer DNA oligonucleotides were purchased from Proligo and sequences are described at Supplementary Table S3.
These in silico results were supported by other model structures (M7, M8 and M9 at Supplementary 3) and parameter uncertainty studies (Supplementary 4).
The onset of thinning implied is similar to that inferred from the youngest exposure age at Supplementary Fig. 4c, 10 ka.
As a comparison, we considered the inhibitory function proposed by Smith et al.33 using the kinetics of the viral load detected in our experiments (M10 at Supplementary 3).
A model selection process by AIC revealed that assuming bacterial clearance with a constant number of functional AMs (model D2 or D3 at Supplementary 2) provided the best fitting to the data in the single T4 group.
A total of 148 bait clones (9.6% of all screened baits) were screened in the presence of 50 mM 3-AT (Supplementary Table 4).
A second gene encoding ASP-AT had a rpkm value above 300, but its transcript abundance was similar to the C3 Alloteropsis and 20 times lower than another gene encoding ASP-AT (supplementary table S2, Supplementary Material online).
One explanation for this prevalence could be due to the higher AT content (Supplementary Fig. 4).
In particular, AT dropout (Supplementary Figure S22A), global sequencing coverage, and coverage uniformity were improved in all experimental FFPE compared with initial FFPE data sets (Supplementary Figure S23A,B).
Indeed, aberrant shapes of double-labelled cells (eGFP-CALR) were observed at P0 but especially at P5 (Supplementary Fig. 4b,d).
