The phrase "at substantial increased risk" is not correct in English.
It should be "at substantially increased risk." You can use it when discussing situations where someone or something faces a significant level of danger or likelihood of harm.
Example: "Individuals with pre-existing health conditions are at substantially increased risk of complications from the virus."
Alternatives: "at significantly higher risk" or "at greatly elevated risk."
Women with BRCA1/ BRCA2 mutations are at substantial increased risk for metachronous contralateral breast cancer throughout the follow-up period.
However, decreased fetal movement at or near the end of the pregnancy places the pregnancy at substantial increased risk of poor pregnancy outcome [ 25- 27].
33 In conclusion, our population-based study provides robust evidence to date that young people with diabetes remain at substantial increased risk of all-cause hospitalisation.
Of concern is the fact that Brent et al. [ 13] found that having a mood disorder and a substance use disorder may put adolescents at a substantial increased risk for suicide.
It shows that screening reduces a small risk of dying from prostate cancer in the future, at the cost of substantial increased risk of being diagnosed with prostate cancer in the short term.
This nationwide cohort study on the relation between maternal HD and adverse birth outcome did not show any increased risk of preterm birth or low birth weight at term, and no substantial increased risk of stillbirth in women with previous HD.
Health consequences are substantial, with sufferers at increased risk of all-cause and cardiovascular mortality, progression to kidney failure, cardiovascular disease (CVD) and hospitalizations [ 2, 3].
Most veterans with posttraumatic stress disorder (PTSD) are not violent, yet research has demonstrated that there is a substantial minority who are at increased risk.
Women who experienced migraine were also not at increased risk of substantial cognitive decline (worst 10% of the distribution of decline).
2 As many as two-thirds of long-term survivors are reported to be at increased risk of substantial morbidity and even mortality, due to adverse late effects secondary to cancer or cancer therapy.
