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Main Outcome Measures: Passive torque-angle curves for both ankles were obtained at study commencement, then at weeks 2, 4, and 5 (ie, during, at the end of, and 1 week after the stretching program).
Body weight was registered at study commencement and daily throughout the 65 days of study period.
At study commencement, research assistants were blind to condition of each troop.
Vital signs were assessed at screening, at study commencement, before administration of each apixaban dose, and at study termination.
However, the majority of participants in all conditions wanted to screen at study commencement (n = 1144/2227, or 51.4%).
All participants were recruited from the Birmingham EIS; the Solihull EIS service was not established at study commencement.
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Twelve-lead ECGs were recorded at screening, study commencement, and study discharge.
At the time of study commencement at each site, a trial workshop is being conducted by a team from the Trial Coordinating Centre.
Most subjects were sedentary at prior to study commencement and no specific guidelines regarding physical activity was provided.
Dose escalation for BMS-188797 started at DLDL 1 80 mg m−2, which, at the time of study commencement, was shown to be safe and active from previous phase I trials.
Second, the baseline PSTRs were not true baseline values as they were obtained at one month after study commencement.
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