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Among its many now-surreal passages is one showing its subject writhing on a futon in his home, moaning at spikes of Tinnitus-like pain in his eardrums.
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In the left graph of Fig. 5, the MSE over the whole CA is plotted while the right graph shows the MSE at the spikes of the CA, i. e., the MSE at the actual cycle frequencies.
The extremal values are taken at the spikes of the bicone.
Mounting evidence suggests that tinnitus can be linked with increased spontaneous neuronal activity [5], [6], [7], [8] leading to the use of drugs targeted at reducing spikes of increased activity.
The frequency of AT-spike promoters (13.02%) exceeds that of GC-spike promoters (8.93%) but indicate proportional relative values in most tissues.
We used a custom written JAVA code which integrates with Matlab and is publicly available (http://www.dendrites.org/~mikilon/Code/CTW). Empirically we find that we need few hundreds of spikes for the algorithm to converge and hence with 53 s of recording at spike rate of ∼10 spikes/s the algorithm yields stable estimates.
Exceptions are tissues from cervix and muscle where the number of CG-spike promoters surpasses the number of AT-spike promoters (Additional file 4).
The occurrence of long poly dA dT) or tandem short poly dA dT) tracts on short distances (>30b) near TSS, could also indicate an involvement of AT-spike and CG-spike promoters in short term critical gene expression.
The developed method has been applied in the analysis of AgNPs in river, lake and wastewater samples, with excellent extraction efficiencies (84.9‒98.8%) for AgNPs at spiking levels of 0.86 and 8.70 μg/L.
At spike levels of 530 and 53 ng/g hydrazine, the mean recoveries from all tobacco product types were within the acceptable range [29] of 70%110%% (Table 1), indicating satisfactory accuracy.
Most short-term booms produce spikes of at least 50-100% away from trend price growth.
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