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Despite the large sample size, we had very few events to meaningfully look at some outcomes such as rhabdomyolysis, neuroleptic malignant syndrome and hypoglycaemia.
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However, teachers who are effective at improving some outcomes often are not equally effective at improving others.
All of the studies reported significant improvements in at least some outcomes following implementation of the programs.
Comprehensive programs addressing all infections were reported to have improved antimicrobial use for at least some outcomes.
Eight studies provided complete results (mean and sd) for subjects with and without SIS for at least some outcomes in the text [ 12, 14, 15], by correspondence [ 6, 7, 16] or measured from figures [ 12, 13, 20].
The cohorts are in very different stages of follow-up and thus have not all reached the ages at which some outcomes, for example, asthma or puberty onset, can be assessed.
We conducted a meta-review [ 22] which showed that online interactive resources to support self-management of asthma can be safe and effective at improving some outcomes such as markers of self-care, activity limitation, quality of life and medication use.
Of those remaining (667) in the study, 494 (83%) returned at least some outcome questionnaires at 90 days, and service outcomes such as readmissions and length of stay were available for 644 participants (23 withdrew).
Most studies stated a clear definition of the immigrant groups (n = 29), excluded bias sufficiently (n = 26), adjusted at least some outcome measures for potential confounders (n = 26) and used the same source population for all immigrant groups (n = 35).
This in turn means that by chance at least some outcome measures will generate favourable results for an intervention; hence, the US Food and Drug Agency FDAA) in conjunction with belimumab-trialists developed the SRI aimed at guarding against the possibility that worsening in overall disease might be masked by apparent improvement in a more narrowly defined manifestation.
However, it is vitally important to see at least some outcome from your class attendance to give you confidence.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com