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At selective sites, wild type alleles mutated to deleterious alleles (m) with selection coefficient s and coefficient of dominance h, so that the three genotypes (++, + m, and mm) had fitness 1, 1 – hs, and 1 – s, respectively.
Why this would occur at selective sites on the plasmalemma remains unknown.
Colocalization is evident for many but not for all puncta, indicating an interaction of the proteins at selective sites of the presynapse.
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However, when there was a microstimulation effect at a disparity selective site, it was generally stronger when the motion stimulus was presented at the disparity preferred at that site.
"We intend to have a more selective site, selling a smaller number of goods at a much higher price".
Comparison of effect on field excitatory postsynaptic potentials and population spike responses indicated that the barbiturates act at selective and pathway-specific sites.
Accordingly, the second generation Notch-sparing γ-secretase inhibitors aimed at selective inhibition of specific sites took the spotlight.
Biosynthetic selectivity is achieved through discriminating transport systems to take the substrate to the reactive site, highly selective conversions at this site, and selective transport systems for the product as well.
In contrast to the MERPs and FishTj groups, the evidence for positive selection affecting the FishBrain lineage was not as clear (p = 0.0747; [see additional file 5: Tande_S4]), and can be considered only to be marginal support for adaptive selection or relaxed selective constraints at three sites (51, 126 and 186).
Specifically, such interactions will result in the rapid accumulation of changes at nonsynonymous (amino acid altering) positions in coding DNA compared with the relatively benign mutations at synonymous sites, a selective regime referred to as positive selection.
Considering the sensitivity, initially we constructed H3 K9 (ARTKQTAR KSTGG) and its respective mutant (H3-L9: ARTKQTAR LSTGG) sensors using substrate chromodomain from HP1 protein, and the split-Renilla luciferase fragments of selective split site at amino acid position 229 (NhRLuc: 1 229; ChRLuc: 229 311).
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