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The average mCherry intensity at the site of protrusions is significantly higher than at retractions (1.06 vs. -0.72 standard deviations above mean fluorescence intensity at the cell periphery; p < 10-6, Student's t-test).
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But others, including the folks at Retraction Watch, wondered why the editor at Remote Sensing, Wolfgang Wagner, didn't simply seek to have the paper retracted?
Alison McCook is an editor at Retraction Watch based in Philadelphia, Pennsylvania.
ORI barred the researcher, Dong-Pyou Han, from participating in PHS-funded research for 3 years, but Grassley has asked why ORI did not make him return federal grant money or impose harsher sanctions (more at Retraction Watch).
The story broke 8 July at Retraction Watch, but the first hint of a conspiracy emerged in May of last year, says Daniel Sherman, head of public affairs at SAGE. "An author (later confirmed to be an innocent party) contacted SAGE after receiving two suspicious e-mails from individuals related to a paper he had submitted to JVC".
Cell locomotion involves a cyclical process that requires cell protrusions at its leading edge and retractions at its trailing edge.
Retraction causes relaxation of cantilever bending, which does not stop at zero force but proceeds to negative values at further retraction.
In our study, at a retraction speed of 2500 nm s−1, I27wt unfolds at approximately 200 pN, whereas I27st unfolds at approximately 290 pN.
The peak adhesion force is 205 eV/Å which occurs at the retraction distance of 1.1 nm.
For dry indentation, the peak adhesion force is 270 eV/Å which occurs at the retraction distance of 2.1 nm.
The rupture forces obtained at different retraction velocities showed different magnitude (Fig. 5C and D) and there were gaps between the zero lines in the approach and retraction traces in the curves captured at fast speed compared to the overlapped zero lines captured at slow speed.
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