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Performance scores were gathered at repeated time points longitudinally on students who were also nested within classes; therefore, a hierarchical or multilevel model (HLM) was required to account for lack of independence between scores.
For the LCGM and GMM, aggregate QIDS-SR sum-scores at repeated time points were used.
As such variations are also likely to occur in randomised clinical trials, researchers should consider assessing postintervention health outcomes at repeated time points.
We then fit a modified R model described by Edwards et al. (3), which allows the direct comparison of the predictive effects of time-varying variables on an outcome measured at repeated time points.
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LCGM and GMM fitting was done using the aggregate QIDS-SR sum scores at the 9 repeated time points.
For 3PCA item-level QIDS data at each of the nine repeated time points were used.
In addition, the nonparametric Wilcoxon rank-sum test at each time point and repeated measures analysis of covariance model accounting for treatment and repeated time measurements within each visit were performed.
This was repeated at 25 time points (in spring) within each year and repeated for all 25 years resulting in a total of 87 500 trajectories per grid cell and for the whole model domain 452 200 000 trajectories.
The confidence and knowledge questions were repeated at the AT and FU time points and the help giving behaviour questions were repeated at FU (to provide staff a sufficient time period to demonstrate the effects of the training on actual practice).
At least two more dose response experiments were repeated at those time points and statistically analyzed as above.
The 3D-GE was repeated at six time points, covering a total period of ∼90 minutes post contrast injection.
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