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(A ) The Spearman correlation at progressive time points compared with the young reference sample for the mother and daughter proteome shows a divergence away from a youthful state for the mother.
Sera obtained at progressive time points from control and EC-TM DNA-vax hamsters were diluted 1 : 100 in PBS-azide-bovine serum albumin (Sigma), and the presence of anti-p185 Ab was determined by flow cytometry using BALB/c 3T3-NKB cells.
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Given the relatively linear relationship observed between load and wire deformation, it is likely that by determining the load deformation ratio (rigidity) of the wires at different time points, progressive stiffening of the system would be observable by this method despite loading of the limb changing between measurements.
Following UVB, 12-HETE became significantly elevated at 18 h (105.85±34.64 pg/mg protein, P=0.007), with a progressive rise at subsequent time points and peak level at 72 h (251.51±60.85 pg/mg protein, P<0.0001) (Fig. 3 C ). Baseline value of 15-HETE was 2.16 ± 1.37 pg/mg protein.
Cells lacked normal nuclear morphology at later time points, consistent with progressive injury (Fig 1C, arrow head).
The variations in severity and dissemination of lung lesions among pigs, especially at later time points, reflect the progressive nature of A. pleuropneumoniae infections with continuous development of new lesions.
Whilst the change in scores from baseline indicated a progressive lightening at the three time points in the gum group, the change in shade scores in the tablet group showed a darkening at weeks 2 and 6 and the mean change from baseline at week 12 was zero.
injection of mice with human serous SKOV-3 OVCA cells or saline control, blood was sampled at various time points while early and progressive carcinomatosis was being modeled.
Notably, at subsequent time points, we observed a progressive decline in FB/CB2R positivity and a parallel rise in FB/CB2R negativity in RSNs.
The substrate with 70 min collecting time illustrated highest progressive calcium deposition at all the time points.
The ovaries of these mice were examined at various time points to determine if there were progressive alterations in epithelial morphology or tumor formation as has been observed in human prophylactic oophorectomy specimens.
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