Sentence examples for at prion from inspiring English sources

Selective breeding of sheep for arginine (R) at prion gene (PRNP) codon 171 confers resistance to classical scrapie.

In wapiti, animals heterozygous or homozygous for leucine at prion protein amino acid 132 (L) have a lengthened CWD incubation period [ 35] and L appears to limit CWD, but not classical scrapie, susceptibility in a transgenic mouse model [ 36].

Furthermore, knowledge on the temporal kinetics of PrPSc accumulation in tissue compartments, which are easily accessible such as muscle may help in devising novel approaches for diagnostic tests, aimed at detecting prion diseases at subclinical stage.

At present, prion diseases are incurable.

Western blot findings could be confirmed by PET-blot of cerebellum showing abundant deposits of PrPSc in monkeys challenged with vCJD and BSE-prions at terminal prion disease and faint PrPSc deposits in a subclinical, vCJD challenged animal (figure 2).

Sequence analysis revealed that both the 2006 US atypical BSE animal and its 2-year-old heifer were heterozygous at bovine prion gene nucleotides 631 through 633 for GAA (glutamic acid) and AAA (lysine).

Overall, our results support the concept that the oxidation of Helix-3 methionines may constitute a crucial effector for triggering the early steps in PrPSc biogenesis and subsequently underscore the importance of the impairment of the methionine redox cycle at the prion birth.

At terminal prion disease, PrPSc and prion infectivity could be observed irrespective of the presence of EAM.

The MPs express further dismay that the government sank public money into a prototype blood test of vCJD at the MRC prion unit at University College London, but had failed to use the test.

We use the term 'prion survival' to refer to the rate at which prions remain bio-available and infectious on the landscape.

Although the sites at which prions invade the human body are disputed, natural infection is supposed to occur orally, especially through the gut.