The hydrophobic core contained Val and Ile residues at positions "a" and Leu residues at positions "d".
The others are at positions 4 and 33.
(iv) The pilot symbols are placed equidistantly at positions (SCEN4).
There are holes at positions ±14 and ±15.
Alanine substitution at positions 2, 3, 4, 6 and 11 17 preserved inhibition, while substitution of alanine at positions 8 and 9 resulted in complete loss of activity.
The Em is −285 mV when cysteines are at positions 121 and 305 and −295 mV when the cysteines are at positions 122 and 305.
New amphiphilic pyridine derivatives containing dodecyloxycarbonyl substituents at positions 3 and 5 and cationic moieties at positions 2 and 6 have been designed and synthesised.
Particularly, substitutions at positions S72, V78 and I263 had an effect on the enzyme regioselectivity.
These variants contained exchanges of the amino acids at positions 36, 37, 39 and 42.
The distinct secondary and tertiary structure models highlighted residues at positions potentially important for CHX17 activity.
Meanwhile, the pressure pulsations at positions of the inlet and outlet with different inflows are investigated.
