The association of NRXN1 polymorphisms with schizophrenia and the age-at-onset of this disease were explored.
In this study, we attempted to investigate the association between the NRXN1 gene polymorphisms and schizophrenia and age-at-onset of this disease in 768 patients with schizophrenia and 738 healthy control subjects of Chinese Han population.
To describe the prevalence and age at onset of the outcome variables in this sample, we calculated their lifetime prevalence per age, separately for boys and girls, and plotted both the absolute prevalence (expressed in percentage of the total sample) and the relative age at onset, that is, the probability of having experienced an onset at a specific age given a lifetime diagnosis of the disorder.
The age at onset of symptoms in this group was younger than observed in bvFTD due to C9orf72 expansions.
Further sub-classification is based on the age at onset of symptoms as this feature can serve as a starting point to prioritise genetic testing (Table 2A).
Although most of our ADPKD patients started RRT with haemodialysis, the prevalence study revealed kidney transplantation to be the most widely used method, as expected based on the age at onset of ESRD in this population.
We found substantial differences in estimated effect size between diabetes and Parkinson's disease by age at onset of Parkinson's disease, although this difference is based on small numbers of patients with early onset.
In this study, we delineate the association body mass index (BMI) has with risk and age at onset of hypertension and explore how this association is modulated by sex and the pre-existing condition of diabetes.
No trends in risk were observed other than for ICU mortality when using this cutoff at onset of ARDS, while a significant trend across the four risk groups was noted using this cutoff after 24 h (Additional file 1: Table E2).
That together with the age at onset of our patients strongly indicate that this is not connected with the Li-Fraumeni syndrome, in which the cancer usually presents at a much earlier age [ 22, 23].
