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TH exerts effects through complex biological pathways, which offer a wealth of opportunities to pharmacologically intervene in TH signalling at numerous steps.
Yet, the Hi-C protocol is still complex and subject to variations at numerous steps that can affect the resulting data.
Experimental interventions to decrease harm from hyperoxia are targeted at numerous steps in the pathway of ROS-induced damage.
Risks were summarized [see Additional file 1] for leukemias and lymphomas vs. mutations or aberrations at numerous steps within the model pathway in Figure 1.
The complex process of AV valve and septum formation, with its multifaceted stages and various signalling pathways involved, would indicate that aberrant AVS development indeed can occur at numerous steps in the process.
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As failure at any of these numerous steps in the process will result in failure of the cell to form a clinically relevant metastatic tumour, it is perhaps not surprising that metastasis is an extremely inefficient process.
For those who have been patients in their own or other emergency departments, they likely encountered numerous steps that at least on the surface appear redundant or wasteful.
It enables the harness-secured patients to practice numerous steps assisted by therapists at an early stage after neurological insult [ 6].
In response, China has taken numerous steps to reassure global investors, customers and consumers at home that "Made in China" is not a warning label.
He argued that the administration has taken numerous steps to improve domestic security, including expanding pharmaceutical stockpiles, stationing inspectors at overseas ports -- including in Shanghai, it was announced today -- and pressing corporations to improve security screening of employees.
Extremely intelligent and often numerous steps ahead of everyone else, she is never short of a sarcastic comment at the expense of slower characters.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com