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We considered methods that allow joint synthesis of sensitivities and specificities at multiple thresholds, but none was appropriate because most studies reported sensitivity and specificity at a single threshold.
For many of the studies, we could extract test accuracy results for protein to creatinine ratio at multiple thresholds; for example, for Al Ragip et al, 29 a two by two table expressing the number of true positives, true negatives, false positives, and false negatives was available for each of five protein to creatinine ratio thresholds (0.13, 0.18, 0.19, 0.2, and 0.49).
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More information can be obtained by applying the same scheme at multiple threshold levels.
Multi-level Otsu method represents an extension of the same basic idea, i.e., minimization of the intra-class variance (which in turn results in maximization of inter-class variance) to images that contain clusters of pixel populations representing different structures that can therefore be classified at multiple threshold levels.
Given the complexity of this process and the sheer number of clinical symptoms and signs elicited (including multiple thresholds at multiple and varying times during the illness), it is highly likely that errors in judgment occur when combining these clinical features.
We demonstrated the similar overlapping community structure in structural brain networks constructed at multiple cost thresholds (Figure 9).
Figure 5G summarizes quantitative evaluations of the automated detection of EPSCs, using the same filter bank at multiple detection thresholds.
Similarly as in the original study of St Onge et al. [10], the prediction capability was evaluated using the receiver operating characteristic (ROC) curves that show the relative trade-off between the sensitivity and specificity of the predictions at multiple decision thresholds (Figure 3).
Coexpression modules are defined at multiple branch thresholds.
Consequently, a test of association of the trait with the super-allele is performed at multiple MAF thresholds, with significance assessed by means of permutation.
We have experimented with multiple thresholds and found out that at low threshold values, the recall is favored.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com