Patient care guidelines are usually implemented one at a time, yet patients are at risk for multiple, often preventable, adverse events simultaneously.
Mature neurons promote survival at all costs by employing multiple, often redundant, strategies to prevent cell death by apoptosis.
We live in a complicated, messy world -- one in which multiple, often contradictory, forces are at play.
For the treatment of multifactorial and complex diseases, it has become increasingly apparent that compounds acting at multiple targets often deliver superior efficacy compared to compounds with high specificity for only a single target.
These data indicate that P. falciparum transcriptional start sites are generally located at multiple loci, often spread over several hundred basepairs, some 150-450 bp upstream of the ORF.
It is increasingly recognized that the genetic variations occurring at multiple loci often perturb signal transduction, regulatory and metabolic pathways, resulting in detrimental changes in phenotype [18].
The multiple, often overlapping, performances get under way at 2 p.m.
Our experience with a GPRD cluster trial 23 and pharmacogenetic study found that this takes enormous effort and time, even for low risk studies, replicated at multiple sites, and often with differing systems.
Meanwhile, CEOs and those in the FIRE sectors have seen their incomes grow by multiples, often subsidised at taxpayer expense, even as their reckless actions have left economic chaos in their wake.
We also found that recurrences after CSA are more often at multiple sites as compared to recurrences after RFA, which are more often at single -and thus potentially surgically treatable- sites.
