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A two-way ANOVA was used for comparing AdGFP vs. AdAcon at multiple doses of PQ2+.
We further confirmed in separate experiments, and at multiple doses of virus, that the ΔA51R virus displays attenuated virulence compared to VACV-WR.
Safety and tolerability data indicate that BAN2401 is well-tolerated at single doses up to 15 mg/kg intravenously and at multiple doses of up to 10 mg/kg intravenously biweekly.
We note that determination of an additive or synergistic interaction between Bouvardin and IR would require measuring the effect of single agents and the combination at multiple doses of each agent.
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BV-9238 at a dose of 0.5 μg/mL and respective known inhibitors were at multiple doses to determine their IC50s.
Based on our preliminary dose-escalating experiments, we identified that TMZ (5 mg/kg) and 2 Gy/kg as minimally efficacious doses at multiple doses instead of one weekly dose and the schedule combination was chosen for our GBM mouse model to yield enhanced survival in combination with MMP14 attenuation.
122 Another Phase II trial of vorinostat conducted in 33 patients with advanced or refractory CTCL at multiple doses demonstrated an ORR of 24% with a median time to response of 3 months and a median duration of response of 3.7 months.
By contrast, mast cell heparin at multiple doses significantly reduced the size and number of colonies of tumor cells co-cultured with fibroblasts, especially in the presence of FGF-7.
Despite observing 25-10025-100%lity following MA-EBOV challenge at multiple doses (fig. S1), we found no evidence of hemorrhagic disease or susceptibility to lethal disease after infection with WT-EBOV.
Despite observing 25 to 100% mortality after MA-EBOV chatlenge at multiple doses (fig. S1), we found no evidence of hemorrhagic disease or susceptibility to lethal disease after infection with WT-EBOV.
Oral Lodamin was administered at multiple doses and durations: 15 mg/kg/day (for 7 days and 14 days of treatment) and 30 mg/kg dose (7 days).
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