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BMS-927711 was well tolerated at single doses up to 1500 mg and at multiple doses up to 600 mg for 14 days.
Despite observing 25-10025-100%lity following MA-EBOV challenge at multiple doses (fig. S1), we found no evidence of hemorrhagic disease or susceptibility to lethal disease after infection with WT-EBOV.
Despite observing 25 to 100% mortality after MA-EBOV chatlenge at multiple doses (fig. S1), we found no evidence of hemorrhagic disease or susceptibility to lethal disease after infection with WT-EBOV.
A two-way ANOVA was used for comparing AdGFP vs. AdAcon at multiple doses of PQ2+.
Here, the biochemical properties, PK/PD, and therapeutic effects of Vela and Imig were directly compared at multiple doses.
Finally, since the average LOD score threshold for a suggestive QTL is 0.59, suggestive QTLs present in all 9 camptothecins at multiple doses should be pursued last.
Similar(35)
In a Phase I/II, clinical activity with minimal toxicity was observed at multiple dose levels in mutant BRAF tumors [9].
Systematic QC involved querying the database for potential inconsistencies (e.g., male-only effects being assigned to female treatment groups, or systemic LOAEL being set at multiple dose levels) along with updating vocabularies and related records.
This phase IIa, multicentre, randomized, placebo-controlled multiple-dose trial assessed the safety and tolerability of sotatercept at multiple dose-levels, and determined the effect of the drug on bone remodelling in MM patients with osteolytic lesions (ClinicalTrials.gov identifier: NCT00747123).
Combination index (CI) values were derived from the median-effect plots of single agents alone or in combination and statistical tests were used to determine whether the CI values at multiple dose-effect levels (IC50, IC25, IC12.5) were statistically significantly different from 1 (P < 0.05).
DTP vaccine is recommended as multiple doses at 2, 3 and 4 months and a booster at 16 months.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com