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Thus, large-scale studies at multiple centres throughout the world will be necessary to confirm these results.
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Because these patients have had multiple MRI studies at multiple centres, we analysed the most recent MRI examination.
The varying uptake highlights the importance of running pilots at multiple centres.
Lastly, we determined the extent to which MRI performed at multiple centres increases the variability compared with MRI at individual centres.
For example, we used a single centre, population based approach; by contrast, the vast majority of large scale interventional trials are undertaken at multiple centres.
Furthermore, in this single-institution study, the therapy given was more homogeneous than it might have been at multiple centres.
The trials took place in various settings and were based in multiple centres throughout the UK.
This study was based on prospectively collected, validated clinical audit data from multiple centres throughout the north-west of England and Wales.
Further research at multiple centers throughout the world is needed.
ESR dating of quartz grains was carried out at CENIEH (Spain) following the Multiple Centre approach as described in25.
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