Sentence examples for at modest doses from inspiring English sources

13, 15– 19 These medications present a high risk of adverse events, even at modest doses, and may favor the progression of cognitive impairment.

Intravenous infusion of the centrally acting alpha adrenoceptor agonist clonidine, at modest doses, significantly attenuates cardiac and renal sympathetic tone in heart failure patients [ 25].

If sepsis is a manifestation of a nonlinear dynamic control system out of control, then filtration at modest doses with a large pore filter may succeed as well as high-volume hemofiltration with a conventional cut-off filter.

Antipsychotic drugs are at high risk of adverse events, even at modest doses, and may interfere with the progression of cognitive impairment and interact with several drugs including anti-arrhythmics and acetylcholinesterase inhibitors.

Our results show that the majority of patients with advanced pancreatic adenocarcinoma and good performance status can tolerate an irinotecan and cisplatin combination at modest doses, but that this combination appears not all that active, with response rates that are in line with other chemotherapy combinations in this disease.

It can significantly increase blood glucose at high doses, but recent studies demonstrate that at modest doses (750 2,000 mg/day), significant improvements in LDL cholesterol, HDL cholesterol, and triglyceride levels are accompanied by only modest changes in glucose that are generally amenable to adjustment of diabetes therapy (266, 267).

Increased dietary selenium intakes reduce the effects of mercury toxicity, although this protective effect is only apparent at low to modest doses of mercury.

Administration of atorvastatin at a modest dose (10 mg daily) to patients presenting with acute coronary syndromes significantly decreased circulating MCP-1 levels [ 32].

However, in all published studies so far, THAM has been used at a modest dose, for a short period of time, and not with the aim of full pH correction.

Specifically, use of a bipolar RFE device with conductive fluid avoids bone necrosis on CT and histology when used on cortical and cancellous bone in vivo with 92% hemostasis and applied at a modest dose of 50 W for 11 seconds in an area of 2.9 cm (190 fluence [f = watts · seconds/cm]) [ 6].

LPS causes liver injury at high doses (Kosai et al. 1999) but a modest, noninjurious inflammation at low doses (Ganey and Roth 2001) in several animal models.