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At the highest dose level, the mixture showed a clear less than additive action of the mycotoxins, as compared to the effects of the five individual compounds, whereas at lower dose levels the mycotoxins behaved additive.
Images at lower dose levels were then simulated using a noise modification routine.
All the compounds exhibited potent anti-ulcer activity at lower dose levels as compared to the standard, omeprazole.
The improvement with IR was generally more pronounced at lower dose levels.Expanding beyond traditional contrast and noise based assessments of IR, we performed both task-specific and task-generic evaluations of IR performance.
Molecular targeted agents might then achieve clinical benefit at lower dose levels than those required with conventional cytotoxic agents.
There were no DLTs at lower dose levels.
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At lower dose level, fold change in the expression levels of miR-124 and miR-155 was observed to be 3.24 (±0.13) and 4.03 (±0.3), respectively.
At lower dose level, fold change in the expression levels of the RANKL, BGLAP, and OPG was observed to be −2.85 (±0.18), −2.1 (±0.20), and 2 (±0.24), respectively.
At lower dose level, fold change in the expression levels of the RUNX2 was observed to be −3.25 (±0.27), whereas at higher dose level the fold change was observed to be −2.15 (±0.13).
Compared to the higher dose of NaF (20 mg/L), elevated levels of miR-124 and miR-155 expressions were seen at lower dose level of NaF (8 mg/L).
After 7 days of daily temozolomide treatment, the percentage decrements in AGAT activity were generally greater at the higher dose levels (125, 150, and 175 mg m−2 day−1) than at the lower dose levels (75 and 100 mg m−2 dalthoughltheugh the small number of patients treated at the lowest dose level were insufficient to provide statistical analysis of the dose-dependence of AGAT inactivation.
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