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However, at low score cut-offs, where high numbers of binding sites are predicted in foreground and background promoters, statistical tests like the exact binomial test can report highly significant P-values for small "fold" differences when these are supported by high counts of binding site instances.
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It appeared that at low scores of j, rj values were clustered close to unity (i.e., similar in real and mock), but at high scores of j, rj tended toward zero (i.e., enriched in real proteins and therefore candidate Cdk substrate) [Figure 1B].
PR tended to occur at low scores of DCA-2, which had substantially less information than DCA-1, but plots of both drainages intermingled.
This implies that there was a higher degree of agreement between raters at low scores than at the moderate scores (10 14) which form the upper end of our data set.
This complex is also predicted by SWC and DECOMP at low scores (ranked 103 and 12 respectively); through voting, our integrated approach re-scores it much higher (second-highest rank).
We found that a fixed difference between scores in GCRS did not have the same meaning at all levels of performance: untransformed scores (on a scale of 0 to 24) showed a higher degree of agreement between raters at low scores than at moderate scores.
The calibration of the Centor criteria was good in the first data set but poor in the second data set with significant differences between the percentages of observed and predicted presence of streptococci at low scores (see online supplementary appendix 2).
Among them, CONS predicted seven with high confidence scores, and one, GO 0000104, at a low score.
One poll published by Megafon, a research institute, on December 21st put the government and its allies at 45%—a low score for a coalition government.
Hence his ruthless finish at TPC Louisiana, where he set a new record low score at the famous course.
Indeed he might have broken the record low score at a major but for a 12-foot putt on the final green that slipped past the hole.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com