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At low proportion (figure 6A), the power of FWCST and FWBST was higher when specificity was lower than ∼0.6.
At low proportion of causative variants, tests that are based on alternative grouping strategies have largely improved power over tests on grouping all variants.
The plots show that the concurrent task little affects the sensitivity defined at low proportion correct (d' = 1; red symbols) but greatly reduces that defined at high proportion correct (d' = 3; blue symbols).
Comparing the two functional variant weighted tests, FWBST was more powerful at low proportion (figure 8A), but had approximately equal power to that FWCST had at the other two proportions (figure 8B and 8C).
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In order to quantify the effect that these mechanisms had on the energy dissipation process, R-curves were generated which suggested that the specimen configuration used here is appropriate for characterising fracture toughness at low proportions of mode II.
First several SDRMs may be genuinely polymorphic occurring at low proportions in the absence of selective drug pressure (albeit below our defined threshold of 0.5%).
The presence of An. funestus was limited to wooded savanna villages only and at low proportions (0.01%).
As none of the tumour samples were found to contain a validated low frequency variant, we used a series of decreasing variant content admixtures as a model system to assess the ability of the method to detect variants at low proportions as could occur in a heterogeneous tumour.
At isolation distances of 800 m, only 3 study areas achieved a positive balance, and this only at lowest proportions of non-GM OSR cropping (5%).
For ST and CMC, at a low proportion of causative variants, 100% power was achieved at heritability levels of 2.0 and 3.0%, respectively.
At a low proportion of causative variants (figure 9A), FWCST, FWBST, and GWWS had the ability to detect genes with heritability of 1.5% with nearly 100% power.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com