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At low intakes (or low nutrient status) there is relatively little response; the effect increases fairly rapidly over a particular intake or exposure range; and then at higher intakes the response plateaus.
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Median ruminal particle size and mean rectal particle size were lower at low intake than at medium and high intakes.
The increase in particle retention time in the rumen at low intake did not result in an increase in digestibility.
Particle retention time in the rumen and in the total tract were higher at low intake than at medium and high intake, whatever the hay.
Ruminal ammonia and non-protein non-ammonia N concentrations, and plasma urea concentration were decreased at low intake and/or low N supply, but there was no evidence that shortage of N compounds for ruminal microbes is responsible for decreased ruminal degradation at low intake.
Recent literature has pointed to the beneficial effect of R-TFA at low intake levels compared with no effect at higher intake levels.
This AMDR for total fat was "estimated based on evidence indicating a risk for CHD [coronary heart disease] at low intake of fat and high intakes of carbohydrate and on evidence for increased obesity and its complications (CHD) at high intakes of fat" (167).
We specifically looked at lowest intake values versus highest intake values.
Further research has to be done in order to explain such disturbances in digestibility at very low intake.
"My GP then sent me to a dietician that time, that was helpful as well you know, kept to that for about a year or two or three and I wandered away from it again….the information on high blood pressure, again I would go to the internet to remind myself about it, you know, the only thing I've kept good at is the low intake of salt you know".
Taken together, depending on the αTOC status, quercetin revealed a αTOC-sparing as well as αTOC-independent antioxidative effect at low αTOC intake.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com