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Four of these 5 patients had not failed treatment at last study visit.
Medication Satisfaction Questionnaire (MSQ) was completed after 14 days of treatment and after 6 weeks at last study visit.
Five patients had an EDSS at baseline of ≤ 6.0; four of these had not failed treatment at last study visit.
EDSS failure or worsening was defined as an increase in the EDSS by ≥ 1 point on any two consecutive measures or at last study visit.
Five of the 8 patients with PPMS had not failed treatment at last study visit, but two of these patients did not have a follow-up beyond 1 year.
An analysis of outcomes between the two treatments at last study visit was conducted, analysing the overall population and subgroups on the basis of prior nephrectomy status, primary cell type, and a number of poor-prognosis factors at baseline.
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At last, studies focusing on disabled, unhealthy, overweight, obese or pregnant participants were excluded.
Changes in sexual functioning were assessed by means of the self-rated Patient Global Impression of Sexual Function (PGI-SF) scale [ 21], which was collected at baseline and at the last study visit.
Women also had smaller aortic valve area both at inclusion and at the last study visit, also when adjusted for pressure recovery in the aortic root, indicating more severe AS (table 1 and figure 1).
The prevalence of LV hypertrophy increased from 36% at baseline to 60% at the last study visit (P<0.01).
Pubertal onset before enrollment was assumed to occur 6 months before enrollment, and boys who were still prepubertal at their last study visit were censored at that visit.
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