Sentence examples for at its locus from inspiring English sources

Furthermore, PRDM14 is overexpressed in 57 75% of breast cancers examined and is correlated with genomic amplification at its locus indicating a causative role [21].

Specific enrichment of Dali at its locus was observed as expected.

The GSTM1 isozyme contains three main genotypes at its locus on chromosome 1p13: GSTM1*b, GSTM1*b and GSTM1*0.

Critically, functional HDAC6 dependency is not associated with genomic alterations at its locus and thus represents a non-oncogene addiction.

In conclusion, we have clearly demonstrated for the first time that RUNX3 is frequently methylated in primary pancreatic cancer tissues, frequent hemizygous deletion occurs at its locus in 1p36, and RUNX3-inactivated cases showed worse survival.

p16 is itself a tumour suppressor; germline mutations at its locus CDKN2A are principally associated with familial melanoma in humans, with some increased incidence of pancreatic cancer, suggesting particular importance in melanocytes (Gruis et al, 1995; Bennett, 2003; Hayward, 2003; Kefford et al, 2004; Gray-Schopfer and Bennett, 2006).

The historical demographic structure of the genetic variation at the ITS locus was investigated using Tajima's D [80] and Fu's Fs [81] in DnaSP 4.5.03 [61].

The maximum level of variation we observed at the nuclear ITS locus (ML distance = 21.26%) is similar to that found in other genera within the Orobanchaceae (Pedicularis [ 77] and Orobanche [ 78]).

We therefore sequenced the ITS locus from at most one representative of each species, unless analyses of the other four markers did not recover its sequences as a clade.

RT-PCR analysis indicates that Fun30 does not regulate ADE2 when it is at its endogenous locus (Figure 4D), showing that its silencing function is linked to the repressed state of the HMR locus.

Confocal fluorescence microscopy z-projections of ∆MICOS cells expressing mito-DsRed and Mic60-EGFP expressed at its endogenous locus (left) or Mic60-FLAG from the MIC60 locus and pMic60-EGFP expressed from the ura3 locus (right).