Exact(31)
Bizelesin-targeted AT islands are likely to function as strong matrix attachment regions (MARs), domains that organize DNA loops on the nuclear matrix.
Bizelesin binds mainly T(A/T 4A sites, which are on average scarce, but occasionally cluster in distinct minisatellite regions (200 1000 bp of ∼85 100% AT), herein referred to as AT islands.
Distortion of MAR-like AT islands may be a basis for the observed inhibition of new replicon initiation and the extreme lethality of bizelesin adducts (<10 adducts/cell for cell growth inhibition).
Passengers got on and off at islands along the way.
They did not stop at islands along the way.
Attendance at Islands of Adventure soared 30 percent in 2011, to about 7.7 million visitors, compared with 2010.
Similar(29)
Hence, long AT-islands represent a novel class of critical targets for anticancer drugs.
The consequences of DNA lesions in AT-islands targeted by bizelesin seem to be dramatically more lethal than non region-specific lesions by tallimustine and cisplatin.
The kitchen has an eat-at island and stainless-steel appliances.
A spokeswoman at Island Def Jam declined to comment.
Maps are available at island visitor information centers.
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