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It is formally possible that at least some of the defective SUB proteins have residual activity but are present at insufficient levels at the cell surface.
Because nuclear retention and DNA replication of extrachromosomal EBV genomes depend on expression of the viral EBNA1 gene we considered that it might be expressed at insufficient levels in mESCs.
Additionally, engaging in physical activity, even at insufficient levels, had a positive effect on the perception of PF in both genders.
The statistical Main and Interaction Effects analyses of Screen 2 as well as the analyses of its individual media compositions resulting in improved growth determined that Ca, Mg, Zn and Mn were for some species being supplied at insufficient levels.
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Thus, the bioavailability of rapamycin might be at an insufficient level in the embryos.
Although these observations suggest that vacuolar sorting of Gap1-152 independentent of its ubiquitylation, Gap1-152 was missorted to the vacuolar membrane in the npi1 mutant in which the Rsp5 ubiquitin ligase is expressed at an insufficient level.
We likewise demonstrate here a dependency on MDM2, as well as Rb, to target p53 for degradation in NPM-ALK-expressing MEFs, albeit at an insufficient level in this case to disrupt p53 function entirely, thus triggering growth arrest and preventing transformation.
Those "ubiquitous" promoters, however, are inadequate for meiotic purposes, because they drive gene expression in meiosis at an insufficient level [ 62].
This capacity is controlled by the calcium homeostatic mechanisms, which, in case of the milk fever cow, are operating at an insufficient level.
The high variability of linezolid levels found in our study, with a substantial proportion at insufficient low levels, might contribute to the observed high mortality rate and severity of infection in ICU patients.
However, systemic toxicities and insufficient levels of IFN at the tumor sites have limited its widespread adoption in treatment schemes.
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