Exact(2)
Since he was showing continuous lactic acidosis, the oral supplementation of dichloroacetate (DCA) was introduced on 31st day of birth at initial dose of 50 mg/kg, followed by maintenance dose of 25 mg/kg/every 12 h.
The baseline value is the average between the value at initial dose and any following (maximum 4) provided during the first 24 h and, for each visit (V1 on day 1, V2 on day 2, V3 on day 3), the average pain intensity between the four (at 7 00, 12 00, 18 00 and 21 00).
Similar(58)
This study shows that patients can tolerate bexarotene at initial doses up to 600 mg/m2/dafterter platinum-based chemotherapy and that bexarotene may have the potential to delay disease progression in patients with advanced non small-cell lunon small-cell previouslungtable or responsive disease following platinum-based cancerherapy.
Methotrexate was given as an intravenous infusion over 1 hour at initial doses of 80-120 mg./m body surface area.
Active rheumatoid arthritis patients were randomly assigned to receive masitinib therapy at initial dosing levels of 3.0 or 6.0 mg/kg per day, administered per os for 12 weeks.
Corticosteroids were given at initial doses of 0.5 mg/kg, 0.75 mg/kg or 1 mg/kg depending on severity (by BILAG score) and type of disease manifestations, followed by a taper regimen.
18– 20 Briefly, the two original studies 18, 19 had a multicenter, randomized, double-blind, parallel group design, consisting of a 2-week washout with placebo, followed by 12 weeks of treatment with olmesartan medoxomil or ramipril at initial doses of 10 or 2.5 mg once daily, respectively.
The first three patients were treated at the initial dose level of irinotecan at 70 mg m−2, and all three patients tolerated the treatment well without DLT.
Infliximab (Remicade®; Centocor, Inc., Malvern, PA, USA) is administered intravenously (IV) at an initial dose of 3 mg/kg at weeks 0 (baseline), 2, and 6, then every 8 weeks thereafter.
Patients randomly assigned to insulin glargine (n = 33) started at an initial dose of 10 IU q.d., injected at bedtime.
Patients were begun on continuously-infused CsA at 2 mg/kg/day (1991 1996), or on NEORAL at an initial dose of 5 mg/kg/day (1996 1999).
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