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The pre-clinical data shown here support the view that combining conventional drugs with netrin-1 interference could lead to superior efficacy as well as a reduction of chemotherapy doses at increased efficacy.
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In recent years, contrast agents with improved characteristics, such as increased efficacy and organ specificity, have been developed.
However, because only one-half of 5-HT neurons are active in such conditions, the question remains whether these promising "presynatpic" results can effectively translate into an increased efficacy at the postsynaptic level.
Alternatively, the same numbers could be released, possibly with increased efficacy because of increased successful mating events.
Increased compliance was associated with increased efficacy.
Increasing doses of NESP corresponded with increased efficacy.
Increasing concentrations of complement system components resulted in increased efficacy of the breast cancer cells killing.
Increasing concentrations of complement system components resulted in increased efficacy of the ovarian cancer cells killing as complement dependent cytotoxicity (CDC).
Doctors who prescribe these newer contraceptive pills should inform their patients of this increased risk, especially since it is not counterbalanced by increased efficacy.
The use of combination anti-VEGF therapy has also been explored addressing the hypothesis that parallel inhibition at different points in the signalling pathway may translate into increased efficacy.
This effect is attributable to the increased efficacy of purifying selection as the population size increases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com