Furthermore, there is a threshold for the tissue uptake of HB-19, thus ruling out any eventual toxic effects at increased doses [39].
** Quinapyramine is too toxic at increased doses and therefore does not figure in the second half of the table.
The sanative action of some of the drugs when administered at increased doses can be read in this right half of the table.
The results of these studies are generally consistent: at increased doses, cannabis impairs the psychomotor skills necessary for safe driving.
Similarly, treatment with low concentrations of Dox and 100 nM 17-DMAG primarily results in cell death through C-Frag; however, at increased doses of Dox apoptosis increases.
The mean kinetic parameters of both enantiomers in goats and sheep at a dose of 5 mg/kg BW and at increased dose rates (10 and 15 mg/kg BW) in goats following SC administrations are given in Table 6.
5 The risk of gastrointestinal adverse events can be reduced by the use of COX-2 selective agents, although their selectivity and impact on overall risk diminishes at increased doses.
But as the depression deepened, I capitulated, using antidepressants in various combinations and at increasing doses.
Female adolescent Sprague Dawley rats were administered morphine at increasing doses (5 25 mg/kg, s.c).
The products were applied at increasing doses, 50 (1 ×), 150 (3 ×), and 300 (6 ×) mg N kg− 1ds, on a sandy loam soil.
Our experiments indicated that repeated administration of nociceptin at increasing doses during conditioning significantly attenuated the reinforcing effect of amphetamine in conditioned place preference paradigm.
