Sentence examples for at gatekeeper from inspiring English sources

In addition, an in vitro resistant screening identified mutation at gatekeeper residue conferred cross-resistance to all known FLT3 inhibitors.

Moreover, the development of resistance against the kinase inhibitors has been reported in MTC due to the mutations at gatekeeper residues, which render the receptor inaccessible to drug binding [ 17, 18].

The growth of BAF3 cells expressing resistant variants of FLT3-ITD was inhibited completely within the range of 800 n M. Interestingly, two FLT3-ITD variants (D839G and Y842H) were found to be hypersensitive to the drug while mutations at gatekeeper residue F691L and D835F/Y showed only twofold resistance to the drug.

Indicative of their mechanism of action, enzyme inhibition by these compounds was found to be sensitive to both the ATP concentration and substitution of the amino acid residue present at the "gatekeeper" position at the ATP-binding site of the enzyme.

This element is similar to the Dive Drop's found on The Swarm at Thorpe Park and GateKeeper at Cedar Point and consists of the train rotating 180 degrees into an upside down position before descending back to the ground.

In contrast with all the other members of the AMP-activated protein kinase (AMPK) family, which possess a large hydrophobic residue at the gatekeeper site, the SIKs have a small threonine residue at this position within its catalytic domain.

While he chafes at the gatekeeper function Apple performs, he said he had no plans to develop products for Android.

He was best known not as one of the barbarians, but rather at the gatekeeper looking out for the post-buyout welfare of the employees, thus living up to his nickname, "Vice-President of Worry".

Unlike common protein kinases, they possess a naturally occurring alanine residue at the "gatekeeper" position, as well as other sequence variations.

Docking study was performed for the active compounds into ATP binding site of EGFR-TK which showed similar binding mode to gefitinib and additional binding with Cys-773 at the gatekeeper of EGFR-TK enzyme.

Many clinically relevant kinases such as Bcr-Abl, c-Kit, EGFR and PDGFR possess a threonine residue at the gatekeeper position that is involved in critical interactions with ATP competitive drugs.