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The initial histological changes after PDT were vascular, followed by full thickness necrosis at 72 h.
During the study one patient had an amputation because of full thickness flap failure at 2 months.
These correlations were limited to a sample of knees with full thickness cartilage lesions at baseline (see the Study Sample section for justification).
To compare the cross-sectional and longitudinal relationships between regional approximate BML volume and the extent of hyaline cartilage damage a sample consisting of 44 knees was selected that only included knees with full thickness cartilage lesions at baseline.
At 6 weeks after grafting, the transplanted tissues underwent full thickness wounding and treatment with fibrin gels containing bound KGF.
Previously, Fang et al. reported a flux value of 1.5 2 μg/cm/h (at pH 5.0) for the diffusion of 5-FU across full thickness nude mouse skin.
Patients who did not seem to have deep burns at primary examination were re-evaluated daily and operated on if full thickness burns (FTBs) were identified.
48 However, these results apply to epidermal sheets isolated by heating at 60°C (which might damage the lipid matrix and corneodesmosomes) and not to full thickness skin.
Despite full thickness necrosis there was no reduction in the colonic bursting pressure at any time.
All subjects were required to be 18 years of age or older, in good general health with no conditions that would significantly impact wound healing, have a body mass index (BMI) ≤28, and were scheduled for at least one full thickness surgical incision of at least 20 cm in length as part of an elective standard abdominoplasty procedure.
We included all patients who had (a) ≥18 years of age, (b) a maximum cartilage defect comprising ≤50% of the full thickness at written radiological report (at our institution all knee MRI's are evaluated by the senior author S.T ., and (c) two standard T2-measurements performed, one at the beginning and one at the end of the MRI scan.
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