Exact(14)
Mean gestational age at first dose of IPT was 21.0 weeks with the community approaches versus 23.1 weeks at health units, P > 0.0001.
Concentrations were simulated every hour, starting at first dose and continuing through steady state.
Postnatal age at first dose of surfactant 18. Prophylactic indomethacin 19.
Age at first dose, the total number of doses (mean, median, range), and the number and percentage of infants with first dose after November 30th were determined.
Age at first dose of MMR vaccine ranged from 10 months to 5 years 9 months and at second dose from 16 months to 6 years.
The majority of patients (that is, 13/17 or 76% at first dose and 9/11 or 81% at steady state) had trough levels ≤10 mg/l.
Similar(45)
This IV busulfan protocol achieved the target AUC of 700 900 µM·min in 54% of patients at second dose.
No patient had a busulfan AUC greater than 1000 µM·min at second dose, so further adjustments were unnecessary.
No dose-limiting toxicity (DLT) was observed at the first dose level; at the 135/25 mg m-2 dose level three out of six patients had a DLT which was considered as unacceptable.
4OHT, hardly detectable at the first dose, was measured at the steady state with high interpatient variability.
Fourteen patients with 17 liver metastases were treated: seven at the first dose level (35 Gy) and seven at the second level (40 Gy).
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