Data on resource utilization as well as on quality of life are collected at baseline, at interim telephone contacts, and during the final assessment.
In order to calculate quality-adjusted life years (QALYs), the EQ-5D questionnaire [ 24] is applied at baseline, at interim telephone contacts, and during the final assessment.
Imaging was performed at baseline and at interim (after 2 cycles of chemotherapy).
He has held posts that include president and chief executive at Nielsen Media Research, chairman at NetRatings and interim chairman at Nielsen Entertainment.
To estimate tumour heterogeneity, the average standard deviations of attenuation values within the tumour volumes were recorded as 22 HU at baseline versus 28 HU at interim for HD, and as 21 HU at baseline versus 27 HU at interim for NHL.
This study was terminated early at a planned interim analysis at 520 deaths.
Differences between groups will be assessed, based on a normal approximation for the DRI score at 12 months postinjury and at interim occasions.
Interim analysis for TQ change at day 12 will be carried out on the first 76 randomized patients following an O'Brien and Fleming type sequential design with overall two-sided significance level 0.05 (0.0052 at interim, 0.0481 at final analysis; [ 38]).
The lesions used for response assessment at interim were localized at nodal sites in 14 patients and in 2 patients at extra nodal sites (Table 2).
As expected, tumour scores at killing were higher than those at interim analysis, but with the same pattern.
