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A comparison was made in mice receiving free drugs at equivalent doses.
Further, the therapeutic effects of the LNP 5-FU formulation, as determined in a HT-29 subcutaneous colorectal cancer model where treatment was given QDx5, was greater than that which could be achieved with free 5-FU when compared at equivalent doses.
We also demonstrated that the disulfide cross-linked micellar formulation of PTX (PTX-DCMs) was more efficacious than both free drug and the non-cross-linked formulation of PTX at equivalent doses of PTX in the ovarian cancer xenograft mouse model.
Alternatively, fentanyl may be used at equivalent doses.
Liposome-entrapped Adriamycin was more effective than free Adriamycin at equivalent doses of the drug.
At equivalent doses, acquisition costs of oral agents are less than intravenous counterparts.
Similar(31)
At equivalent dose levels, platinum particles of 8 nm in size did not induce apparent toxic effects in renal tissues by acute or chronic administration.
Indeed, simulations of sclerostin mAb administration at equivalent dose levels, but at different dosing intervals, demonstrate that higher P1NP levels can be achieved by dosing in longer intervals, because levels of pre-osteoblasts have time to recover between doses.
It consisted of a 4 week control phase (patients continued their usual regimen), a 4-week treatment phase (patients received CLE at equivalent dose) and a 2-week follow up period (patients returned to their baseline treatment).
Genes that are shared by both expression signatures represent genomic biomarkers of subchronic and chronic exposure to two AhR ligands at toxic equivalent doses.
Liver tumor incidence was not equivalent among AhR ligands but instead was higher in animals exposed to TCDD and PCB126 compared with animals exposed to PeCDF at toxicologically equivalent doses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com