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As a result, the search space becomes smaller at each step of the optimization procedure.
Piecewise Cubic Hermite Interpolating Polynomial (PCHIP) has been used for fin-surface representation at each step of the optimization process with control points as the design variables.
Taking triangular cross-section as the initial profile, the fin shape is represented by Piecewise Cubic Hermite Interpolating Polynomial (PCHIP) at each step of the optimization process with control points as the design variables.
At each step of the optimization procedure, every possible edge or position addition, removal or edge reversal that produces a valid, acyclic network is evaluated, and the alteration that increases the score ℓ′ the most is kept.
This strategy eliminates the need for numerical system integration at each step of the optimization process, which is expensive because S-systems can be numerically stiff, just like most other nonlinear models.
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At each step of optimization, scores were re-calculated according to modified parameters, binding sites with the highest score were selected for each gene, and then these scores were compared between training genes and control genes using t-statistics.
Section 3 details the resolution steps of the optimization problem.
Briefly, the Master problem described in step 3 of the optimization procedure constructs a relaxation of the original feasible space by constructing supporting hyper planes at the point of interest.
For more complex PK/PD models, the calculation may be significantly slower, because each dose calculation involves an optimization (e.g., to assure that plasma concentration is above a certain threshold at a specific timepoint), and each evaluation step in the optimization requires numerical integration of the ordinary differential equations of the model.
Zone of inhibition was observed against Mycobacterium smegmatis ATCC 9341 at every step of media optimization.
It is important to note that, the model, being a step-wise model, determines the parameters through an optimization procedure (optimization being with respect to the residual sum of squares at each step in the model).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com