Hospitalisations and mortality will be recorded by GPs at each planned visiting case report form.
At each planned and unplanned visit to the general practice treatment will be adjusted with support of an internet-based asthma monitoring system supervised by a central coordinating specialist nurse.
At each planned and unplanned visit during the 12 months follow-up maintenance, therapy will be adjusted according to the relevant algorithm, using the internet-based asthma monitoring system by either the nurse practitioner or general practitioner [ 17].
We synchronized cultures using multiple 5%% sorbitol solution treatments [ 101], and expanded cultures to accommodate harvesting of at least 50 mL of culture at each planned time-point (time course 1: every ~4 h for 56 h; time course 2: ~4 h before and after the ring to trophozoite and trophozoite to schizont morphological stage transitions).
All patients were screened for latent or active tuberculosis (TB) by an interferon γ-release assay using QuantiFERON-TB Gold in tube (QTF-TB Gold-IT, Cellestis, Australia) and chest x-ray and monitored for any clinical signs and symptoms of TB at each planned visit.
Patient utilities will additionally be assessed by the time-trade-off method by telephonic interview and a web-page (e-TTO) at each planned and unplanned period (exacerbation) [ 39] - indirect utilities from the general public will be obtained using the SF-6D [ 37, 34] and EQ-5D [ 40, 41].
Therefore, in most real-world scenarios computing a complete and sound (valid) plan at each (re- planning step is not wore- planningutational restepces and tise required to genotate the plan.
The system consists of (M) machines to be distributed over (N) distinct locations ((N= M)) and reconfiguration may take place at the beginning of each planning period.
The production planner can typically run this customized DSS at the beginning of each planning period (commonly one working day), and after making the decision about final changes on the detailed schedule, data of production order is extracted.
The team leader uses timeboxed iteration cycles to track progress of completed tasks and features as development progresses and at each iteration planning meeting, the development team breaks down features into tasks and assigns tasks to team members.
