Sentence examples for at domains from inspiring English sources

Phylogenetic analysis of the C-terminal AT domains identified the C. pecorum ATs as belonging to 6 gene families.

Their relative positions suggest AT domains are being displaced from cis-AT PKSs over time.

Our phylogenetic analysis of type I PKSs in algae supports an evolutionary scenario whereby integrated AT domains were displaced to yield trans-AT PKSs.

In systems such as the 6-deoxyerythronolide B synthase (DEBS), each AT domain is paired with its own ACP domain; these ATs are typically referred to as cis-acting AT domains (Scheme 1A).

While most PKS assembly lines contain dedicated acyltransferase (AT) domains harbored within each module, several systems utilize stand-alone ATs that act in trans.

Our data suggest that in algae, cis-AT domains are characteristic for iterative (unimodular) PKSs, and vice versa, noniterative (multimodular) PKSs generally lack integrated AT domains.

In turn, these quantitative insights led us to predict the efficacy with which the two trans-AT domains would complement a mutant of the DEBS assembly line in which a single AT domain had been catalytically inactivated.

We have also evaluated the implications of the mechanistic analysis of both trans-AT domains by determining their ability to complement the entire DEBS assembly line harboring a module-specific AT lesion.

Most trans-AT domains are specific for malonyl-CoA.

trans-AT domains (Fig.  1) are iteratively used to acylate each module [ 32].

Like clade 3, clade 4 contains iterative type I PKSs with cis-AT domains.