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The observation that the distinct medullary stromal cell-types induce Treg-differentiation at distinct doses of antigenic peptide in vitro, suggests that the stromal cell with which thymocytes interact in vivo may in part determine the choice between deletion and Treg-differentiation (Wirnsberger et al., 2009).
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The animals were treated with two distinct doses of ERZO.
In addition, our results appeared to show distinct dose dependence of the two p53 dynamic modes.
Our hypothesis to explain our results with such distinct dose delivery is the participation of some non-targeted effects.
In this work, we investigate the potential benefit of delivering distinct dose distributions in different fractions.
At lunch, the effect of GI on glucose and insulin levels became more pronounced, and a distinct dose-response relationship between glucose or insulin AUC and GL was apparent.
At daily colistin doses of 9 m.
Dose-escalation was performed in a 3 + 3 design at doses of 1.5, 2, 3 and 4 mg/kg.
Using three NMC cell lines established in our laboratory, we assessed the relative cytotoxicity of 61 anticancer compounds representing 17 distinct drug classes, at a fixed dose of 10 μ M. We performed unsupervised hierarchical clustering on viability to identify patterns of response among the drug classes.
In the long-term culture system, 20% of the studied AML samples showed a distinct decrease in cell expansion that was already observed at low dose of dasatinib (0.5 nM).
In 20% of the cases (3/15), a distinct decrease in long-term cell expansion of AML CD34+ cells was already observed at a dose of 0.5 nM dasatinib, ranging from 48%to91%1% inhibition as compared to the untreated group.
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