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Of all 352 TB patients assessed at deterioration, 182 (52%) did not culture M.tb at both tuberculosis diagnosis and at deterioration.
Forty-one patients who at initial TB diagnosis were culture negative (n = 11) or no culture was sent (n = 30), subsequently cultured M.tb at deterioration.
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Diagnosis at clinical deterioration and outcome at 24 weeks were determined for all patients.
The estimated MID using the BI as the basis for the anchor-based method ranged from 0.09 at minimal improvement to 0.12 at minimal deterioration for the EQ-5D index, whereas it ranged from 0.04 at minimal deterioration to 0.14 at minimal improvement for the SF-6D index.
In 11% (39/352) of cases, no tuberculosis cultures were sent at initial tuberculosis diagnosis and at clinical deterioration.
Biological specimens were obtained at tuberculosis diagnosis, at 8 and 20 weeks' follow-up and at clinical deterioration.
During the course of our study, DST was performed at tuberculosis diagnosis, at 8 and 20 weeks of follow-up and at clinical deterioration.
Of 73 patients who had rifampin sensitive M.tb at initial tuberculosis diagnosis, eight (11%) cultured rifampin resistant M.tb at clinical deterioration.
Without exception, they expressed alarm and anger at the deterioration they see.
Only a blackened fingernail hints at the deterioration of an actual body.
But the lack of cooperation on North Korea only hints at the deterioration in the U.S.-China relationship.
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CEO of Professional Science Editing for Scientists @ prosciediting.com