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We show that chronic metabolic inflammation is apparent in the visceral AT depot at 24 weeks of HFD-feeding (Fig. 3), whilst overt hepatic inflammation does not occur until 40 weeks of HFD-feeding (Fig. 4).
Higher MMP-2 mRNA expression in the SC AT suggests that in horses, this AT depot is more stimulated to differentiate pre-adipocytes into adipocytes [ 10, 41] and extracellular matrix remodeling [ 11].
It is possible that if more fat is deposited in an AT depot with high mRNA expression levels of pro-inflammatory cytokines, such as nuchal AT with high leptin and pro-inflammatory IL-6 mRNA expression, this may contribute to a greater overall inflammation in that individual horse than if the fat had been deposited in an AT depot with a low mRNA expression of pro-inflammatory cytokines.
No significant AT depot effect was found for interleukin 6 and superoxide dismutase 2 (P > 0.05).
To date, there have been no systematic studies of AT depot associations with biomarkers.
In humans, the major visceral AT depot corresponds to the greater omentum, a large fold of the peritoneum.
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Multiple linear regression was used to model the relationship between changes in AT depots and changes in metabolic variables.
Because of their skewed distribution, AT depots were log2-transformed in all regression analyses (associations with the outcome are per doubling).
Numerous differences in gene expression were seen between OM and SQ AT depots, and between pregnant and non-pregnant groups (Fig. 3a).
Models were constructed in a staged fashion using HIV status, demographics (age, sex, and race), lifestyle factors, and MRI AT depots as predictor variables.
To address that concern, military logistics planners have been massing hundreds of huge tanker trucks at depots in Kuwait.
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