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Of these, 78 had acquired AT deficiency (plasma level below 70%) at onset of renal supportive therapy, 40 in the first 2-year period and 38 in the last 2-year period.
Hereditary AT deficiency is associated with an excessive tendency toward clot formation, and manifestations of this defect are recurrent thrombophlebitis and pulmonary embolism.
Critically ill patients with acquired antithrombin (AT) deficiency, may have a shorter filter lifespan.
Heparin resistance can be caused by mechanisms independent of AT or mechanisms related to AT deficiency.
To describe the outcome of pregnancy in women with inherited antithrombin (AT) deficiency.
Although antithrombin III (AT) was not examined, AT deficiency was also suspected because of increasing needs of heparin dose during ECMO therapy.
Similar(23)
Conclusions:These results represent the initial steps toward a novel approach to the gene therapy of α1-AT deficiency.
Methods:Therapy of human α1-AT deficiency requires stable transduction of resting hepatocytes, both to deliver wild-type α1-AT and to inhibit production of mutant α1-AT.
Because of the promise of recombinant simian virus 40 (rSvectorsctors, we tested their ability to deliver a transgene and to target a transcript for destruction by direct administration of the vectors to the liver of an animal model for human α1-antitrypsin (α1-AT) deficiency.
Patients with α1-AT deficiency were excluded.
CT-scan, pulmonary function tests and α1-AT deficiency were systematically documented.
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